Receptor Interactive Protein Kinase 3 Promotes Cisplatin-Triggered Necrosis in Apoptosis-Resistant Esophageal Squamous Cell Carcinoma Cells
Identifieur interne : 001745 ( Main/Exploration ); précédent : 001744; suivant : 001746Receptor Interactive Protein Kinase 3 Promotes Cisplatin-Triggered Necrosis in Apoptosis-Resistant Esophageal Squamous Cell Carcinoma Cells
Auteurs : Yang Xu [République populaire de Chine] ; Zhengwei Lin [République populaire de Chine] ; Nan Zhao [République populaire de Chine] ; Lanping Zhou [République populaire de Chine] ; Fang Liu [République populaire de Chine] ; Zbigniew Cichacz [États-Unis] ; Lin Zhang [États-Unis] ; Qimin Zhan [République populaire de Chine] ; Xiaohang Zhao [République populaire de Chine]Source :
- PLoS ONE [ 1932-6203 ] ; 2014.
Descripteurs français
- KwdFr :
- Animaux, Antinéoplasiques (pharmacologie), Apoptose (), Apoptose (génétique), Carcinome épidermoïde (anatomopathologie), Carcinome épidermoïde (génétique), Carcinome épidermoïde (métabolisme), Charge tumorale (), Charge tumorale (génétique), Cisplatine (pharmacologie), Facteur de nécrose tumorale alpha (biosynthèse), Humains, Interférence par ARN, Lignée cellulaire tumorale, Modèles animaux de maladie humaine, Nécrose (), Nécrose (génétique), Protéines et peptides de signalisation intracellulaire (déficit), Protéines mitochondriales (déficit), Receptor-Interacting Protein Serine-Threonine Kinases (génétique), Receptor-Interacting Protein Serine-Threonine Kinases (métabolisme), Régulation de l'expression des gènes tumoraux (), Souris, Techniques de knock-out de gènes, Tests d'activité antitumorale sur modèle de xénogreffe, Transduction du signal, Tumeurs de l'oesophage (anatomopathologie), Tumeurs de l'oesophage (génétique), Tumeurs de l'oesophage (métabolisme).
- MESH :
- anatomopathologie : Carcinome épidermoïde, Tumeurs de l'oesophage.
- biosynthèse : Facteur de nécrose tumorale alpha.
- déficit : Protéines et peptides de signalisation intracellulaire, Protéines mitochondriales.
- génétique : Apoptose, Carcinome épidermoïde, Charge tumorale, Nécrose, Receptor-Interacting Protein Serine-Threonine Kinases, Tumeurs de l'oesophage.
- métabolisme : Carcinome épidermoïde, Receptor-Interacting Protein Serine-Threonine Kinases, Tumeurs de l'oesophage.
- pharmacologie : Antinéoplasiques, Cisplatine.
- Animaux, Apoptose, Charge tumorale, Humains, Interférence par ARN, Lignée cellulaire tumorale, Modèles animaux de maladie humaine, Nécrose, Régulation de l'expression des gènes tumoraux, Souris, Techniques de knock-out de gènes, Tests d'activité antitumorale sur modèle de xénogreffe, Transduction du signal.
English descriptors
- KwdEn :
- Animals, Antineoplastic Agents (pharmacology), Apoptosis (drug effects), Apoptosis (genetics), Carcinoma, Squamous Cell (genetics), Carcinoma, Squamous Cell (metabolism), Carcinoma, Squamous Cell (pathology), Cell Line, Tumor, Cisplatin (pharmacology), Disease Models, Animal, Esophageal Neoplasms (genetics), Esophageal Neoplasms (metabolism), Esophageal Neoplasms (pathology), Gene Expression Regulation, Neoplastic (drug effects), Gene Knockout Techniques, Humans, Intracellular Signaling Peptides and Proteins (deficiency), Mice, Mitochondrial Proteins (deficiency), Necrosis (chemically induced), Necrosis (genetics), RNA Interference, Receptor-Interacting Protein Serine-Threonine Kinases (genetics), Receptor-Interacting Protein Serine-Threonine Kinases (metabolism), Signal Transduction, Tumor Burden (drug effects), Tumor Burden (genetics), Tumor Necrosis Factor-alpha (biosynthesis), Xenograft Model Antitumor Assays.
- MESH :
- chemical , biosynthesis : Tumor Necrosis Factor-alpha.
- chemical , deficiency : Intracellular Signaling Peptides and Proteins, Mitochondrial Proteins.
- chemical , genetics : Receptor-Interacting Protein Serine-Threonine Kinases.
- chemical , metabolism : Receptor-Interacting Protein Serine-Threonine Kinases.
- chemical , pharmacology : Antineoplastic Agents, Cisplatin.
- chemically induced : Necrosis.
- drug effects : Apoptosis, Gene Expression Regulation, Neoplastic, Tumor Burden.
- genetics : Apoptosis, Carcinoma, Squamous Cell, Esophageal Neoplasms, Necrosis, Tumor Burden.
- metabolism : Carcinoma, Squamous Cell, Esophageal Neoplasms.
- pathology : Carcinoma, Squamous Cell, Esophageal Neoplasms.
- Animals, Cell Line, Tumor, Disease Models, Animal, Gene Knockout Techniques, Humans, Mice, RNA Interference, Signal Transduction, Xenograft Model Antitumor Assays.
Abstract
Cisplatin-based chemotherapy is currently the standard treatment for locally advanced esophageal cancer. Cisplatin has been shown to induce both apoptosis and necrosis in cancer cells, but the mechanism by which programmed necrosis is induced remains unknown. In this study, we provide evidence that cisplatin induces necrotic cell death in apoptosis-resistant esophageal cancer cells. This cell death is dependent on RIPK3 and on necrosome formation via autocrine production of TNFα. More importantly, we demonstrate that RIPK3 is necessary for cisplatin-induced killing of esophageal cancer cells because inhibition of RIPK1 activity by necrostatin or knockdown of RIPK3 significantly attenuates necrosis and leads to cisplatin resistance. Moreover, microarray analysis confirmed an anti-apoptotic molecular expression pattern in esophageal cancer cells in response to cisplatin. Taken together, our data indicate that RIPK3 and autocrine production of TNFα contribute to cisplatin sensitivity by initiating necrosis when the apoptotic pathway is suppressed or absent in esophageal cancer cells. These data provide new insight into the molecular mechanisms underlying cisplatin-induced necrosis and suggest that RIPK3 is a potential marker for predicting cisplatin sensitivity in apoptosis-resistant and advanced esophageal cancer.
Url:
DOI: 10.1371/journal.pone.0100127
PubMed: 24959694
PubMed Central: 4069059
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000146
- to stream Pmc, to step Curation: 000146
- to stream Pmc, to step Checkpoint: 000797
- to stream PubMed, to step Corpus: 002A92
- to stream PubMed, to step Curation: 002A77
- to stream PubMed, to step Checkpoint: 002A77
- to stream Ncbi, to step Merge: 002683
- to stream Ncbi, to step Curation: 002683
- to stream Ncbi, to step Checkpoint: 002683
- to stream Main, to step Merge: 001792
- to stream Main, to step Curation: 001745
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Receptor Interactive Protein Kinase 3 Promotes Cisplatin-Triggered Necrosis in Apoptosis-Resistant Esophageal Squamous Cell Carcinoma Cells</title><author><name sortKey="Xu, Yang" sort="Xu, Yang" uniqKey="Xu Y" first="Yang" last="Xu">Yang Xu</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>State Key Laboratory of Molecular Oncology, Cancer Institute & Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Molecular Oncology, Cancer Institute & Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Lin, Zhengwei" sort="Lin, Zhengwei" uniqKey="Lin Z" first="Zhengwei" last="Lin">Zhengwei Lin</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>State Key Laboratory of Molecular Oncology, Cancer Institute & Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Molecular Oncology, Cancer Institute & Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Zhao, Nan" sort="Zhao, Nan" uniqKey="Zhao N" first="Nan" last="Zhao">Nan Zhao</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>State Key Laboratory of Molecular Oncology, Cancer Institute & Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Molecular Oncology, Cancer Institute & Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Zhou, Lanping" sort="Zhou, Lanping" uniqKey="Zhou L" first="Lanping" last="Zhou">Lanping Zhou</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>State Key Laboratory of Molecular Oncology, Cancer Institute & Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Molecular Oncology, Cancer Institute & Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Liu, Fang" sort="Liu, Fang" uniqKey="Liu F" first="Fang" last="Liu">Fang Liu</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>State Key Laboratory of Molecular Oncology, Cancer Institute & Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Molecular Oncology, Cancer Institute & Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Cichacz, Zbigniew" sort="Cichacz, Zbigniew" uniqKey="Cichacz Z" first="Zbigniew" last="Cichacz">Zbigniew Cichacz</name><affiliation wicri:level="2"><nlm:aff id="aff3"><addr-line>Biodesign Institute, Arizona State University, Tempe, Arizona, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Biodesign Institute, Arizona State University, Tempe, Arizona</wicri:regionArea><placeName><region type="state">Arizona</region></placeName></affiliation></author><author><name sortKey="Zhang, Lin" sort="Zhang, Lin" uniqKey="Zhang L" first="Lin" last="Zhang">Lin Zhang</name><affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>Departments of Pharmacology and Chemical Biology, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Pharmacology and Chemical Biology, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Zhan, Qimin" sort="Zhan, Qimin" uniqKey="Zhan Q" first="Qimin" last="Zhan">Qimin Zhan</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>State Key Laboratory of Molecular Oncology, Cancer Institute & Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Molecular Oncology, Cancer Institute & Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Zhao, Xiaohang" sort="Zhao, Xiaohang" uniqKey="Zhao X" first="Xiaohang" last="Zhao">Xiaohang Zhao</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>State Key Laboratory of Molecular Oncology, Cancer Institute & Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Molecular Oncology, Cancer Institute & Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff4"><addr-line>Center of Basic Medical Sciences, Navy General Hospital, Beijing, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Center of Basic Medical Sciences, Navy General Hospital, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24959694</idno><idno type="pmc">4069059</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4069059</idno><idno type="RBID">PMC:4069059</idno><idno type="doi">10.1371/journal.pone.0100127</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000146</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000146</idno><idno type="wicri:Area/Pmc/Curation">000146</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000146</idno><idno type="wicri:Area/Pmc/Checkpoint">000797</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000797</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">002A92</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002A92</idno><idno type="wicri:Area/PubMed/Curation">002A77</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002A77</idno><idno type="wicri:Area/PubMed/Checkpoint">002A77</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002A77</idno><idno type="wicri:Area/Ncbi/Merge">002683</idno><idno type="wicri:Area/Ncbi/Curation">002683</idno><idno type="wicri:Area/Ncbi/Checkpoint">002683</idno><idno type="wicri:Area/Main/Merge">001792</idno><idno type="wicri:Area/Main/Curation">001745</idno><idno type="wicri:Area/Main/Exploration">001745</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Receptor Interactive Protein Kinase 3 Promotes Cisplatin-Triggered Necrosis in Apoptosis-Resistant Esophageal Squamous Cell Carcinoma Cells</title><author><name sortKey="Xu, Yang" sort="Xu, Yang" uniqKey="Xu Y" first="Yang" last="Xu">Yang Xu</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>State Key Laboratory of Molecular Oncology, Cancer Institute & Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Molecular Oncology, Cancer Institute & Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Lin, Zhengwei" sort="Lin, Zhengwei" uniqKey="Lin Z" first="Zhengwei" last="Lin">Zhengwei Lin</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>State Key Laboratory of Molecular Oncology, Cancer Institute & Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Molecular Oncology, Cancer Institute & Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Zhao, Nan" sort="Zhao, Nan" uniqKey="Zhao N" first="Nan" last="Zhao">Nan Zhao</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>State Key Laboratory of Molecular Oncology, Cancer Institute & Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Molecular Oncology, Cancer Institute & Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Zhou, Lanping" sort="Zhou, Lanping" uniqKey="Zhou L" first="Lanping" last="Zhou">Lanping Zhou</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>State Key Laboratory of Molecular Oncology, Cancer Institute & Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Molecular Oncology, Cancer Institute & Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Liu, Fang" sort="Liu, Fang" uniqKey="Liu F" first="Fang" last="Liu">Fang Liu</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>State Key Laboratory of Molecular Oncology, Cancer Institute & Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Molecular Oncology, Cancer Institute & Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Cichacz, Zbigniew" sort="Cichacz, Zbigniew" uniqKey="Cichacz Z" first="Zbigniew" last="Cichacz">Zbigniew Cichacz</name><affiliation wicri:level="2"><nlm:aff id="aff3"><addr-line>Biodesign Institute, Arizona State University, Tempe, Arizona, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Biodesign Institute, Arizona State University, Tempe, Arizona</wicri:regionArea><placeName><region type="state">Arizona</region></placeName></affiliation></author><author><name sortKey="Zhang, Lin" sort="Zhang, Lin" uniqKey="Zhang L" first="Lin" last="Zhang">Lin Zhang</name><affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>Departments of Pharmacology and Chemical Biology, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Pharmacology and Chemical Biology, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Zhan, Qimin" sort="Zhan, Qimin" uniqKey="Zhan Q" first="Qimin" last="Zhan">Qimin Zhan</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>State Key Laboratory of Molecular Oncology, Cancer Institute & Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Molecular Oncology, Cancer Institute & Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Zhao, Xiaohang" sort="Zhao, Xiaohang" uniqKey="Zhao X" first="Xiaohang" last="Zhao">Xiaohang Zhao</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>State Key Laboratory of Molecular Oncology, Cancer Institute & Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Molecular Oncology, Cancer Institute & Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff4"><addr-line>Center of Basic Medical Sciences, Navy General Hospital, Beijing, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Center of Basic Medical Sciences, Navy General Hospital, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antineoplastic Agents (pharmacology)</term><term>Apoptosis (drug effects)</term><term>Apoptosis (genetics)</term><term>Carcinoma, Squamous Cell (genetics)</term><term>Carcinoma, Squamous Cell (metabolism)</term><term>Carcinoma, Squamous Cell (pathology)</term><term>Cell Line, Tumor</term><term>Cisplatin (pharmacology)</term><term>Disease Models, Animal</term><term>Esophageal Neoplasms (genetics)</term><term>Esophageal Neoplasms (metabolism)</term><term>Esophageal Neoplasms (pathology)</term><term>Gene Expression Regulation, Neoplastic (drug effects)</term><term>Gene Knockout Techniques</term><term>Humans</term><term>Intracellular Signaling Peptides and Proteins (deficiency)</term><term>Mice</term><term>Mitochondrial Proteins (deficiency)</term><term>Necrosis (chemically induced)</term><term>Necrosis (genetics)</term><term>RNA Interference</term><term>Receptor-Interacting Protein Serine-Threonine Kinases (genetics)</term><term>Receptor-Interacting Protein Serine-Threonine Kinases (metabolism)</term><term>Signal Transduction</term><term>Tumor Burden (drug effects)</term><term>Tumor Burden (genetics)</term><term>Tumor Necrosis Factor-alpha (biosynthesis)</term><term>Xenograft Model Antitumor Assays</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Antinéoplasiques (pharmacologie)</term><term>Apoptose ()</term><term>Apoptose (génétique)</term><term>Carcinome épidermoïde (anatomopathologie)</term><term>Carcinome épidermoïde (génétique)</term><term>Carcinome épidermoïde (métabolisme)</term><term>Charge tumorale ()</term><term>Charge tumorale (génétique)</term><term>Cisplatine (pharmacologie)</term><term>Facteur de nécrose tumorale alpha (biosynthèse)</term><term>Humains</term><term>Interférence par ARN</term><term>Lignée cellulaire tumorale</term><term>Modèles animaux de maladie humaine</term><term>Nécrose ()</term><term>Nécrose (génétique)</term><term>Protéines et peptides de signalisation intracellulaire (déficit)</term><term>Protéines mitochondriales (déficit)</term><term>Receptor-Interacting Protein Serine-Threonine Kinases (génétique)</term><term>Receptor-Interacting Protein Serine-Threonine Kinases (métabolisme)</term><term>Régulation de l'expression des gènes tumoraux ()</term><term>Souris</term><term>Techniques de knock-out de gènes</term><term>Tests d'activité antitumorale sur modèle de xénogreffe</term><term>Transduction du signal</term><term>Tumeurs de l'oesophage (anatomopathologie)</term><term>Tumeurs de l'oesophage (génétique)</term><term>Tumeurs de l'oesophage (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Tumor Necrosis Factor-alpha</term></keywords><keywords scheme="MESH" type="chemical" qualifier="deficiency" xml:lang="en"><term>Intracellular Signaling Peptides and Proteins</term><term>Mitochondrial Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Receptor-Interacting Protein Serine-Threonine Kinases</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Receptor-Interacting Protein Serine-Threonine Kinases</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antineoplastic Agents</term><term>Cisplatin</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Carcinome épidermoïde</term><term>Tumeurs de l'oesophage</term></keywords><keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Facteur de nécrose tumorale alpha</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Necrosis</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Apoptosis</term><term>Gene Expression Regulation, Neoplastic</term><term>Tumor Burden</term></keywords><keywords scheme="MESH" qualifier="déficit" xml:lang="fr"><term>Protéines et peptides de signalisation intracellulaire</term><term>Protéines mitochondriales</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Apoptosis</term><term>Carcinoma, Squamous Cell</term><term>Esophageal Neoplasms</term><term>Necrosis</term><term>Tumor Burden</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Apoptose</term><term>Carcinome épidermoïde</term><term>Charge tumorale</term><term>Nécrose</term><term>Receptor-Interacting Protein Serine-Threonine Kinases</term><term>Tumeurs de l'oesophage</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Carcinoma, Squamous Cell</term><term>Esophageal Neoplasms</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Carcinome épidermoïde</term><term>Receptor-Interacting Protein Serine-Threonine Kinases</term><term>Tumeurs de l'oesophage</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Carcinoma, Squamous Cell</term><term>Esophageal Neoplasms</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antinéoplasiques</term><term>Cisplatine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Line, Tumor</term><term>Disease Models, Animal</term><term>Gene Knockout Techniques</term><term>Humans</term><term>Mice</term><term>RNA Interference</term><term>Signal Transduction</term><term>Xenograft Model Antitumor Assays</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Apoptose</term><term>Charge tumorale</term><term>Humains</term><term>Interférence par ARN</term><term>Lignée cellulaire tumorale</term><term>Modèles animaux de maladie humaine</term><term>Nécrose</term><term>Régulation de l'expression des gènes tumoraux</term><term>Souris</term><term>Techniques de knock-out de gènes</term><term>Tests d'activité antitumorale sur modèle de xénogreffe</term><term>Transduction du signal</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Cisplatin-based chemotherapy is currently the standard treatment for locally advanced esophageal cancer. Cisplatin has been shown to induce both apoptosis and necrosis in cancer cells, but the mechanism by which programmed necrosis is induced remains unknown. In this study, we provide evidence that cisplatin induces necrotic cell death in apoptosis-resistant esophageal cancer cells. This cell death is dependent on RIPK3 and on necrosome formation via autocrine production of TNFα. More importantly, we demonstrate that RIPK3 is necessary for cisplatin-induced killing of esophageal cancer cells because inhibition of RIPK1 activity by necrostatin or knockdown of RIPK3 significantly attenuates necrosis and leads to cisplatin resistance. Moreover, microarray analysis confirmed an anti-apoptotic molecular expression pattern in esophageal cancer cells in response to cisplatin. Taken together, our data indicate that RIPK3 and autocrine production of TNFα contribute to cisplatin sensitivity by initiating necrosis when the apoptotic pathway is suppressed or absent in esophageal cancer cells. These data provide new insight into the molecular mechanisms underlying cisplatin-induced necrosis and suggest that RIPK3 is a potential marker for predicting cisplatin sensitivity in apoptosis-resistant and advanced esophageal cancer.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Parkin, Dm" uniqKey="Parkin D">DM Parkin</name></author><author><name sortKey="Bray, F" uniqKey="Bray F">F Bray</name></author><author><name sortKey="Ferlay, J" uniqKey="Ferlay J">J Ferlay</name></author><author><name sortKey="Pisani, P" uniqKey="Pisani P">P Pisani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jemal, A" uniqKey="Jemal A">A Jemal</name></author><author><name sortKey="Bray, F" uniqKey="Bray F">F Bray</name></author><author><name sortKey="Center, Mm" uniqKey="Center M">MM Center</name></author><author><name sortKey="Ferlay, J" uniqKey="Ferlay J">J Ferlay</name></author><author><name sortKey="Ward, E" uniqKey="Ward E">E Ward</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ilson, Dh" uniqKey="Ilson D">DH Ilson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jin, Z" uniqKey="Jin Z">Z Jin</name></author><author><name sortKey="El Deiry, Ws" uniqKey="El Deiry W">WS El-Deiry</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Riedl, Sj" uniqKey="Riedl S">SJ Riedl</name></author><author><name sortKey="Shi, Y" uniqKey="Shi Y">Y Shi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hanahan, D" uniqKey="Hanahan D">D Hanahan</name></author><author><name sortKey="Weinberg, Ra" uniqKey="Weinberg R">RA Weinberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, D" uniqKey="Wang D">D Wang</name></author><author><name sortKey="Lippard, Sj" uniqKey="Lippard S">SJ Lippard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kaiser, Wj" uniqKey="Kaiser W">WJ Kaiser</name></author><author><name sortKey="Upton, Jw" uniqKey="Upton J">JW Upton</name></author><author><name sortKey="Long, Ab" uniqKey="Long A">AB Long</name></author><author><name sortKey="Livingston Rosanoff, D" uniqKey="Livingston Rosanoff D">D Livingston-Rosanoff</name></author><author><name sortKey="Daley Bauer, Lp" uniqKey="Daley Bauer L">LP Daley-Bauer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Welz, Ps" uniqKey="Welz P">PS Welz</name></author><author><name sortKey="Wullaert, A" uniqKey="Wullaert A">A Wullaert</name></author><author><name sortKey="Vlantis, K" uniqKey="Vlantis K">K Vlantis</name></author><author><name sortKey="Kondylis, V" uniqKey="Kondylis V">V Kondylis</name></author><author><name sortKey="Fernandez Majada, V" uniqKey="Fernandez Majada V">V Fernandez-Majada</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Miller, Cr" uniqKey="Miller C">CR Miller</name></author><author><name sortKey="Dunham, Cp" uniqKey="Dunham C">CP Dunham</name></author><author><name sortKey="Scheithauer, Bw" uniqKey="Scheithauer B">BW Scheithauer</name></author><author><name sortKey="Perry, A" uniqKey="Perry A">A Perry</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Eilber, Fc" uniqKey="Eilber F">FC Eilber</name></author><author><name sortKey="Rosen, G" uniqKey="Rosen G">G Rosen</name></author><author><name sortKey="Eckardt, J" uniqKey="Eckardt J">J Eckardt</name></author><author><name sortKey="Forscher, C" uniqKey="Forscher C">C Forscher</name></author><author><name sortKey="Nelson, Sd" uniqKey="Nelson S">SD Nelson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kravchenko Balasha, N" uniqKey="Kravchenko Balasha N">N Kravchenko-Balasha</name></author><author><name sortKey="Mizrachy Schwartz, S" uniqKey="Mizrachy Schwartz S">S Mizrachy-Schwartz</name></author><author><name sortKey="Klein, S" uniqKey="Klein S">S Klein</name></author><author><name sortKey="Levitzki, A" uniqKey="Levitzki A">A Levitzki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sharma, A" uniqKey="Sharma A">A Sharma</name></author><author><name sortKey="Ramanjaneyulu, A" uniqKey="Ramanjaneyulu A">A Ramanjaneyulu</name></author><author><name sortKey="Ray, R" uniqKey="Ray R">R Ray</name></author><author><name sortKey="Rajeswari, Mr" uniqKey="Rajeswari M">MR Rajeswari</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cui, Q" uniqKey="Cui Q">Q Cui</name></author><author><name sortKey="Jiang, W" uniqKey="Jiang W">W Jiang</name></author><author><name sortKey="Guo, J" uniqKey="Guo J">J Guo</name></author><author><name sortKey="Liu, C" uniqKey="Liu C">C Liu</name></author><author><name sortKey="Li, D" uniqKey="Li D">D Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bajpai, J" uniqKey="Bajpai J">J Bajpai</name></author><author><name sortKey="Gamnagatti, S" uniqKey="Gamnagatti S">S Gamnagatti</name></author><author><name sortKey="Kumar, R" uniqKey="Kumar R">R Kumar</name></author><author><name sortKey="Sreenivas, V" uniqKey="Sreenivas V">V Sreenivas</name></author><author><name sortKey="Sharma, Mc" uniqKey="Sharma M">MC Sharma</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vanlangenakker, N" uniqKey="Vanlangenakker N">N Vanlangenakker</name></author><author><name sortKey="Bertrand, Mj" uniqKey="Bertrand M">MJ Bertrand</name></author><author><name sortKey="Bogaert, P" uniqKey="Bogaert P">P Bogaert</name></author><author><name sortKey="Vandenabeele, P" uniqKey="Vandenabeele P">P Vandenabeele</name></author><author><name sortKey="Vanden Berghe, T" uniqKey="Vanden Berghe T">T Vanden Berghe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="He, S" uniqKey="He S">S He</name></author><author><name sortKey="Wang, L" uniqKey="Wang L">L Wang</name></author><author><name sortKey="Miao, L" uniqKey="Miao L">L Miao</name></author><author><name sortKey="Wang, T" uniqKey="Wang T">T Wang</name></author><author><name sortKey="Du, F" uniqKey="Du F">F Du</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hitomi, J" uniqKey="Hitomi J">J Hitomi</name></author><author><name sortKey="Christofferson, De" uniqKey="Christofferson D">DE Christofferson</name></author><author><name sortKey="Ng, A" uniqKey="Ng A">A Ng</name></author><author><name sortKey="Yao, J" uniqKey="Yao J">J Yao</name></author><author><name sortKey="Degterev, A" uniqKey="Degterev A">A Degterev</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Galluzzi, L" uniqKey="Galluzzi L">L Galluzzi</name></author><author><name sortKey="Kepp, O" uniqKey="Kepp O">O Kepp</name></author><author><name sortKey="Kroemer, G" uniqKey="Kroemer G">G Kroemer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sun, L" uniqKey="Sun L">L Sun</name></author><author><name sortKey="Wang, H" uniqKey="Wang H">H Wang</name></author><author><name sortKey="Wang, Z" uniqKey="Wang Z">Z Wang</name></author><author><name sortKey="He, S" uniqKey="He S">S He</name></author><author><name sortKey="Chen, S" uniqKey="Chen S">S Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vandenabeele, P" uniqKey="Vandenabeele P">P Vandenabeele</name></author><author><name sortKey="Galluzzi, L" uniqKey="Galluzzi L">L Galluzzi</name></author><author><name sortKey="Vanden Berghe, T" uniqKey="Vanden Berghe T">T Vanden Berghe</name></author><author><name sortKey="Kroemer, G" uniqKey="Kroemer G">G Kroemer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hughes, Ma" uniqKey="Hughes M">MA Hughes</name></author><author><name sortKey="Langlais, C" uniqKey="Langlais C">C Langlais</name></author><author><name sortKey="Cain, K" uniqKey="Cain K">K Cain</name></author><author><name sortKey="Macfarlane, M" uniqKey="Macfarlane M">M MacFarlane</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, J" uniqKey="Li J">J Li</name></author><author><name sortKey="Mcquade, T" uniqKey="Mcquade T">T McQuade</name></author><author><name sortKey="Siemer, Ab" uniqKey="Siemer A">AB Siemer</name></author><author><name sortKey="Napetschnig, J" uniqKey="Napetschnig J">J Napetschnig</name></author><author><name sortKey="Moriwaki, K" uniqKey="Moriwaki K">K Moriwaki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, Dw" uniqKey="Zhang D">DW Zhang</name></author><author><name sortKey="Shao, J" uniqKey="Shao J">J Shao</name></author><author><name sortKey="Lin, J" uniqKey="Lin J">J Lin</name></author><author><name sortKey="Zhang, N" uniqKey="Zhang N">N Zhang</name></author><author><name sortKey="Lu, Bj" uniqKey="Lu B">BJ Lu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Declercq, W" uniqKey="Declercq W">W Declercq</name></author><author><name sortKey="Vanden Berghe, T" uniqKey="Vanden Berghe T">T Vanden Berghe</name></author><author><name sortKey="Vandenabeele, P" uniqKey="Vandenabeele P">P Vandenabeele</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shimada, Y" uniqKey="Shimada Y">Y Shimada</name></author><author><name sortKey="Imamura, M" uniqKey="Imamura M">M Imamura</name></author><author><name sortKey="Wagata, T" uniqKey="Wagata T">T Wagata</name></author><author><name sortKey="Yamaguchi, N" uniqKey="Yamaguchi N">N Yamaguchi</name></author><author><name sortKey="Tobe, T" uniqKey="Tobe T">T Tobe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xu, Y" uniqKey="Xu Y">Y Xu</name></author><author><name sortKey="Zhou, L" uniqKey="Zhou L">L Zhou</name></author><author><name sortKey="Huang, J" uniqKey="Huang J">J Huang</name></author><author><name sortKey="Liu, F" uniqKey="Liu F">F Liu</name></author><author><name sortKey="Yu, J" uniqKey="Yu J">J Yu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Loder, S" uniqKey="Loder S">S Loder</name></author><author><name sortKey="Fakler, M" uniqKey="Fakler M">M Fakler</name></author><author><name sortKey="Schoeneberger, H" uniqKey="Schoeneberger H">H Schoeneberger</name></author><author><name sortKey="Cristofanon, S" uniqKey="Cristofanon S">S Cristofanon</name></author><author><name sortKey="Leibacher, J" uniqKey="Leibacher J">J Leibacher</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Irizarry, Ra" uniqKey="Irizarry R">RA Irizarry</name></author><author><name sortKey="Ooi, Sl" uniqKey="Ooi S">SL Ooi</name></author><author><name sortKey="Wu, Z" uniqKey="Wu Z">Z Wu</name></author><author><name sortKey="Boeke, Jd" uniqKey="Boeke J">JD Boeke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huang Da, W" uniqKey="Huang Da W">W Huang da</name></author><author><name sortKey="Sherman, Bt" uniqKey="Sherman B">BT Sherman</name></author><author><name sortKey="Lempicki, Ra" uniqKey="Lempicki R">RA Lempicki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Livak, Kj" uniqKey="Livak K">KJ Livak</name></author><author><name sortKey="Schmittgen, Td" uniqKey="Schmittgen T">TD Schmittgen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lash, Lh" uniqKey="Lash L">LH Lash</name></author><author><name sortKey="Putt, Da" uniqKey="Putt D">DA Putt</name></author><author><name sortKey="Hueni, Se" uniqKey="Hueni S">SE Hueni</name></author><author><name sortKey="Krause, Rj" uniqKey="Krause R">RJ Krause</name></author><author><name sortKey="Elfarra, Aa" uniqKey="Elfarra A">AA Elfarra</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cho, Ys" uniqKey="Cho Y">YS Cho</name></author><author><name sortKey="Challa, S" uniqKey="Challa S">S Challa</name></author><author><name sortKey="Moquin, D" uniqKey="Moquin D">D Moquin</name></author><author><name sortKey="Genga, R" uniqKey="Genga R">R Genga</name></author><author><name sortKey="Ray, Td" uniqKey="Ray T">TD Ray</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu, Yt" uniqKey="Wu Y">YT Wu</name></author><author><name sortKey="Tan, Hl" uniqKey="Tan H">HL Tan</name></author><author><name sortKey="Huang, Q" uniqKey="Huang Q">Q Huang</name></author><author><name sortKey="Sun, Xj" uniqKey="Sun X">XJ Sun</name></author><author><name sortKey="Zhu, X" uniqKey="Zhu X">X Zhu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fortes, Gb" uniqKey="Fortes G">GB Fortes</name></author><author><name sortKey="Alves, Ls" uniqKey="Alves L">LS Alves</name></author><author><name sortKey="De Oliveira, R" uniqKey="De Oliveira R">R de Oliveira</name></author><author><name sortKey="Dutra, Ff" uniqKey="Dutra F">FF Dutra</name></author><author><name sortKey="Rodrigues, D" uniqKey="Rodrigues D">D Rodrigues</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, Dd" uniqKey="Li D">DD Li</name></author><author><name sortKey="Sun, T" uniqKey="Sun T">T Sun</name></author><author><name sortKey="Wu, Xq" uniqKey="Wu X">XQ Wu</name></author><author><name sortKey="Chen, Sp" uniqKey="Chen S">SP Chen</name></author><author><name sortKey="Deng, R" uniqKey="Deng R">R Deng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, W" uniqKey="Chen W">W Chen</name></author><author><name sortKey="Zhou, Z" uniqKey="Zhou Z">Z Zhou</name></author><author><name sortKey="Li, L" uniqKey="Li L">L Li</name></author><author><name sortKey="Zhong, Cq" uniqKey="Zhong C">CQ Zhong</name></author><author><name sortKey="Zheng, X" uniqKey="Zheng X">X Zheng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Eschenburg, G" uniqKey="Eschenburg G">G Eschenburg</name></author><author><name sortKey="Eggert, A" uniqKey="Eggert A">A Eggert</name></author><author><name sortKey="Schramm, A" uniqKey="Schramm A">A Schramm</name></author><author><name sortKey="Lode, Hn" uniqKey="Lode H">HN Lode</name></author><author><name sortKey="Hundsdoerfer, P" uniqKey="Hundsdoerfer P">P Hundsdoerfer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, Lj" uniqKey="Zhang L">LJ Zhang</name></author><author><name sortKey="Hao, Yz" uniqKey="Hao Y">YZ Hao</name></author><author><name sortKey="Hu, Cs" uniqKey="Hu C">CS Hu</name></author><author><name sortKey="Ye, Y" uniqKey="Ye Y">Y Ye</name></author><author><name sortKey="Xie, Qp" uniqKey="Xie Q">QP Xie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sancho Martinez, Sm" uniqKey="Sancho Martinez S">SM Sancho-Martinez</name></author><author><name sortKey="Piedrafita, Fj" uniqKey="Piedrafita F">FJ Piedrafita</name></author><author><name sortKey="Cannata Andia, Jb" uniqKey="Cannata Andia J">JB Cannata-Andia</name></author><author><name sortKey="Lopez Novoa, Jm" uniqKey="Lopez Novoa J">JM Lopez-Novoa</name></author><author><name sortKey="Lopez Hernandez, Fj" uniqKey="Lopez Hernandez F">FJ Lopez-Hernandez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gonzalez, Vm" uniqKey="Gonzalez V">VM Gonzalez</name></author><author><name sortKey="Fuertes, Ma" uniqKey="Fuertes M">MA Fuertes</name></author><author><name sortKey="Alonso, C" uniqKey="Alonso C">C Alonso</name></author><author><name sortKey="Perez, Jm" uniqKey="Perez J">JM Perez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ramesh, G" uniqKey="Ramesh G">G Ramesh</name></author><author><name sortKey="Reeves, Wb" uniqKey="Reeves W">WB Reeves</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhao, J" uniqKey="Zhao J">J Zhao</name></author><author><name sortKey="Jitkaew, S" uniqKey="Jitkaew S">S Jitkaew</name></author><author><name sortKey="Cai, Z" uniqKey="Cai Z">Z Cai</name></author><author><name sortKey="Choksi, S" uniqKey="Choksi S">S Choksi</name></author><author><name sortKey="Li, Q" uniqKey="Li Q">Q Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roychowdhury, S" uniqKey="Roychowdhury S">S Roychowdhury</name></author><author><name sortKey="Mcmullen, Mr" uniqKey="Mcmullen M">MR McMullen</name></author><author><name sortKey="Pisano, Sg" uniqKey="Pisano S">SG Pisano</name></author><author><name sortKey="Liu, X" uniqKey="Liu X">X Liu</name></author><author><name sortKey="Nagy, Le" uniqKey="Nagy L">LE Nagy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lin, J" uniqKey="Lin J">J Lin</name></author><author><name sortKey="Li, H" uniqKey="Li H">H Li</name></author><author><name sortKey="Yang, M" uniqKey="Yang M">M Yang</name></author><author><name sortKey="Ren, J" uniqKey="Ren J">J Ren</name></author><author><name sortKey="Huang, Z" uniqKey="Huang Z">Z Huang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Degterev, A" uniqKey="Degterev A">A Degterev</name></author><author><name sortKey="Hitomi, J" uniqKey="Hitomi J">J Hitomi</name></author><author><name sortKey="Germscheid, M" uniqKey="Germscheid M">M Germscheid</name></author><author><name sortKey="Ch En, Il" uniqKey="Ch En I">IL Ch'en</name></author><author><name sortKey="Korkina, O" uniqKey="Korkina O">O Korkina</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Festjens, N" uniqKey="Festjens N">N Festjens</name></author><author><name sortKey="Vanden Berghe, T" uniqKey="Vanden Berghe T">T Vanden Berghe</name></author><author><name sortKey="Cornelis, S" uniqKey="Cornelis S">S Cornelis</name></author><author><name sortKey="Vandenabeele, P" uniqKey="Vandenabeele P">P Vandenabeele</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fuertes, Ma" uniqKey="Fuertes M">MA Fuertes</name></author><author><name sortKey="Castilla, J" uniqKey="Castilla J">J Castilla</name></author><author><name sortKey="Alonso, C" uniqKey="Alonso C">C Alonso</name></author><author><name sortKey="Perez, Jm" uniqKey="Perez J">JM Perez</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Wainford, Rd" uniqKey="Wainford R">RD Wainford</name></author><author><name sortKey="Weaver, Rj" uniqKey="Weaver R">RJ Weaver</name></author><author><name sortKey="Hawksworth, Gm" uniqKey="Hawksworth G">GM Hawksworth</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Muscella, A" uniqKey="Muscella A">A Muscella</name></author><author><name sortKey="Urso, L" uniqKey="Urso L">L Urso</name></author><author><name sortKey="Calabriso, N" uniqKey="Calabriso N">N Calabriso</name></author><author><name sortKey="Vetrugno, C" uniqKey="Vetrugno C">C Vetrugno</name></author><author><name sortKey="Rochira, A" uniqKey="Rochira A">A Rochira</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ogawa, Y" uniqKey="Ogawa Y">Y Ogawa</name></author><author><name sortKey="Nishioka, A" uniqKey="Nishioka A">A Nishioka</name></author><author><name sortKey="Hamada, N" uniqKey="Hamada N">N Hamada</name></author><author><name sortKey="Terashima, M" uniqKey="Terashima M">M Terashima</name></author><author><name sortKey="Inomata, T" uniqKey="Inomata T">T Inomata</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baud, V" uniqKey="Baud V">V Baud</name></author><author><name sortKey="Karin, M" uniqKey="Karin M">M Karin</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li><li>États-Unis</li></country><region><li>Arizona</li><li>Pennsylvanie</li></region><settlement><li>Pékin</li></settlement></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Xu, Yang" sort="Xu, Yang" uniqKey="Xu Y" first="Yang" last="Xu">Yang Xu</name></noRegion><name sortKey="Lin, Zhengwei" sort="Lin, Zhengwei" uniqKey="Lin Z" first="Zhengwei" last="Lin">Zhengwei Lin</name><name sortKey="Liu, Fang" sort="Liu, Fang" uniqKey="Liu F" first="Fang" last="Liu">Fang Liu</name><name sortKey="Zhan, Qimin" sort="Zhan, Qimin" uniqKey="Zhan Q" first="Qimin" last="Zhan">Qimin Zhan</name><name sortKey="Zhao, Nan" sort="Zhao, Nan" uniqKey="Zhao N" first="Nan" last="Zhao">Nan Zhao</name><name sortKey="Zhao, Xiaohang" sort="Zhao, Xiaohang" uniqKey="Zhao X" first="Xiaohang" last="Zhao">Xiaohang Zhao</name><name sortKey="Zhao, Xiaohang" sort="Zhao, Xiaohang" uniqKey="Zhao X" first="Xiaohang" last="Zhao">Xiaohang Zhao</name><name sortKey="Zhou, Lanping" sort="Zhou, Lanping" uniqKey="Zhou L" first="Lanping" last="Zhou">Lanping Zhou</name></country><country name="États-Unis"><region name="Arizona"><name sortKey="Cichacz, Zbigniew" sort="Cichacz, Zbigniew" uniqKey="Cichacz Z" first="Zbigniew" last="Cichacz">Zbigniew Cichacz</name></region><name sortKey="Zhang, Lin" sort="Zhang, Lin" uniqKey="Zhang L" first="Lin" last="Zhang">Lin Zhang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Amérique/explor/PittsburghV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001745 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001745 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Amérique
|area= PittsburghV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:4069059
|texte= Receptor Interactive Protein Kinase 3 Promotes Cisplatin-Triggered Necrosis in Apoptosis-Resistant Esophageal Squamous Cell Carcinoma Cells
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:24959694" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a PittsburghV1
| This area was generated with Dilib version V0.6.38. |  |